Reoperative planning of thoracoscopic amputation of the left atrium appendage in atrial fibrillation
Abstract
Atrial fibrillation is the most common atrial tachyarrhythmia worldwide. The risks of systemic thromboembolic events are significantly increased in patients with atrial fibrillation. In this patient group, it is thought that up to 95% of the thrombus is thought to be localised in the left atrial appendage. An important problem of modern arrhythmology is the search for optimal and effective methods of prevention of thromboembolic events in atrial fibrillation. Although the therapeutic methods are proven to be highly effective, this method has a number of limitations and contraindications in lifelong administration.
Surgical isolation or exclusion of the auricle of the left appendage is an alternative option, but this procedure is only possible as a simultaneous procedure in open cardiac surgery.
Occluder implantation is a promising direction in isolation of the left atrial appendage, but has a high dependence on the anatomical structure of the anatomy of the latter and requires the administration of antiaggregants in the postoperative period.
Due to high traumatic nature of open surgical interventions and technical difficulties of occluder implantation, methods of isolation of the left atrial appendage from the systemic blood flow from minimally invasive accesses have been developed. Video-assisted thoracoscopic ablations are not only a promising way to perform epicardial ablation, but also offer the possibility of performing a one-stage left atrial appendage exclusion.
An unresolved challenge of minimally invasive surgical isolation of the left atrial appendage is its detailed visualisation at the surgical planning stage. Computed tomography with contrast has a high resolution, which together with the ability to build three-dimensional models allows a more accurate selection of the size, type and optimal position of the occluding device for the patient according to his anatomical features. Thus, the main objective of the presented report was to describe the role of contrast-enhanced computed tomography at the planning stage of thoracoscopic left atrial appendage endostapler amputation to improve the safety and efficacy of the procedure.
About the Authors
M. KadyirovaRussian Federation
Madina Kadyrova - MD, PhD, head of the Ultrasound diagnostics
27, Bolshaya Serpukhovskaya Str., Moscow, 117997
E. D. Strebkova
Russian Federation
Elizaveta D. Strebkova - MD, PhD, Researcher at the Department of Electrophysiological and Endovascular Imageguided Methods of Diagnosis and Treatment of Arrhythmias № 1
27, Bolshaya Serpukhovskaya Str., Moscow, 117997
E. V. Yalova
Russian Federation
Evgeniya V. Yalova - MD, Junior Researcher of the Ultrasound diagnostics department
27, Bolshaya Serpukhovskaya Str., Moscow, 117997
A. Sh. Revishvili
Russian Federation
Amiran Sh. Revishvili - аcademician of the Russian Academy of Sciences, MD, PhD, General Director; Head of the Department of Angiology, Cardiovascular, Endovascular Surgery and Arrhythmology n.a. ac. A.V. Pokrovsky
27, Bolshaya Serpukhovskaya Str., Moscow, 117997
2/1, bld.1, Barrikadnaya St., Moscow, 125993
References
1. Arakelyan MG, Bockeria LA, Vasilieva EYu, et al. 2020 Clinical guidelines for Atrial fibrillation and atrial flutter. Russian Journal of Cardiology. 2021; 26(7): 4594. DOI: 10.15829/1560-4071-2021-4594 [In Russ].
2. Kolbin AS, Mosikyan AA, Tatarsky BA. Socioeconomic burden of atrial fibrillations in russia: seven-year trends (2010-2017). Journal of Arrhythmology. 2018; (92): 42-48. [In Russ].
3. Krijthe BP, Kunst A, Benjamin EJ, et al. Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060. Eur Heart J. 2013; 34(35): 2746-2751. DOI: 10.1093/eurheartj/eht280
4. Filatov AG, Tarashvili EG. Epidemiology and social significance of atrial fibrillation. Annals of arrhythmology. 2012; 2: 5-13. [In Russ].
5. Piccini JP, Hammill BG, Sinner MF, et al. Clinical course of atrial fibrillation in older adults: the importance of cardiovascular events beyond stroke. Eur Heart J. 2014; 35(4): 250-256. DOI: 10.1093/eurheartj/eht483
6. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke. 1991; 22(8): 983-988. DOI: 10.1161/01.str.22.8.983
7. Safavi-Naeini P, Rasekh A. Thromboembolism in Atrial Fibrillation: Role of the Left Atrial Appendage. Card Electrophysiol Clin. 2020; 12(1): 13-20. DOI:10.1016/j.ccep.2019.11.003
8. Abbara S, Blanke P, Maroules CD, et al. SCCT guidelines for the performance and acquisition of coronary computed tomographic angiography: a report of the society of Cardiovascular Computed Tomography Guidelines Committee: Endorsed by the North American Society for Cardiovascular Imaging (NASCI). J Cardiovasc Comput Tomogr. 2016; 10: 435–449. DOI:10.1016/j.jcct.2016.10.002
9. Deitelzweig S, Bergrath E, di Fusco M, et al. Real-world evidence comparing oral anticoagulants in non-valvular atrial fibrillation: a systematic review and network meta-analysis. Future Cardiol. 2022; 18(5): 393-405. DOI:10.2217/fca-2021-0120
10. Słodowska K, Szczepanek E, Dudkiewicz D, et al. Morphology of the Left Atrial Appendage: Introduction of a New Simplified Shape-Based Classification System. Heart Lung Circ. 2021; 30(7): 1014-1022. DOI:10.1016/j.hlc.2020.12.006
11. Kawabata M, Goya M, Maeda S, et al. A Survey of Direct Oral Anticoagulant Cessation in General Surgery and Outcomes in Patients with Nonvalvular Atrial Fibrillation. Int Heart J. 2020; 61(5): 905-912. DOI:10.1536/ihj.19-625
12. Revishvili AS, Kadirova M, Strebkova ED, et al. Left atrial appendage exclusion using a stapler with thoracoscopic ablation of atrial fibrillation. Complex Issues of Cardiovascular Diseases. 2023; 12(1): 58-71. DOI: 10.17802/2306-1278-2023-12-1-58-71 [In Russ].
13. Healey JS, Crystal E, Lamy A, et al. Left Atrial Appendage Occlusion Study (LAAOS): results of a randomized controlled pilot study of left atrial appendage occlusion during coronary bypass surgery in patients at risk for stroke. Am Heart J. 2005; 150(2): 288-93. DOI: 10.1016/j.ahj.2004.09.054
14. Whitlock R, Healey J, Vincent J, et al. Rationale and design of the Left Atrial Appendage Occlusion Study (LAAOS) III. Ann Cardiothorac Surg. 2014; 3(1): 45-54. DOI:10.3978/j.issn.2225-319x.2013.12.06
15. Osmancik P, Budera P, Zdarska J, et al. Residual echocardiographic and computed tomography findings after thoracoscopic occlusion of the left atrial appendage using the AtriClip PRO device. Interact Cardiovasc Thorac Surg. 2018; 26(6): 919-925. DOI: 10.1093/icvts/ivx427
16. Santana JM, Rosell FM, Dave B. Intraoperative echocardiographic contrast opacifies the left atrial appendage and assists in surgical exclusion. Ann Card Anaesth. 2022; 25(1): 77-80. DOI: 10.4103/aca.aca_192_20
17. Oda S, Honda K, Yoshimura A, et al. 256-Slice coronary computed tomographic angiography in patients with atrial fibrillation: optimal reconstruction phase and image quality. Eur Radiol. 2016; 26: 55–63. DOI: 10.1007/s00330-015-3822-0
18. Shinbane JS. Cardiovascular computed tomographic angiography in patients with atrial fibrillation: challenges of anatomy, physiology, and electrophysiology. J Cardiovasc Comput Tomogr. 2008; 2: 181–182. DOI: 10.1016/j.jcct. 2008.04.001
19. Kondo T, Kumamaru KK, Fujimoto S, et al. Prospective ECG-gated coronary 320-MDCT angiography with absolute acquisition delay strategy for patients with persistent atrial fibrillation. AJR Am J Roentgenol. 2013; 201: 1197–1203. DOI: 10.2214/ajr.12.10140
20. Wen B, Xu L, Liang J, et al. A preliminary study of computed tomography coronary angiography within a single cardiac cycle in patients with atrial fibrillation using 256-row detector computed tomography. J Comput Assist Tomogr. 2018; 42: 277–281. DOI: 10.1097/rct.0000000000000683
21. Xu B, Betancor J, Sato K, et al. Computed tomography measurement of the left atrial appendage for optimal sizing of the Watchman device. J Cardiovasc Comput Tomogr. 2018; 12: 50–55. DOI: 10.1016/j.jcct.2017.11.012
22. Henry TS, Hammer MM, Little BP, et al. Smoke: how to differentiate flow-related artifacts from pathology on thoracic computed tomographic angiography. J Thorac Imaging. 2019; 34: W109–w120. DOI: 10.1097/rti.0000000000000429
23. Bilchick KC, Mealor A, Gonzalez J, et al. Effectiveness of integrating delayed computed tomography angiography imaging for left atrial appendage thrombus exclusion into the care of patients undergoing ablation of atrial fibrillation. Heart Rhythm. 2016; 13: 12–19. DOI: 10.1016/j.hrthm.2015.09.002
24. Romero J, Husain SA, Kelesidis I, et al. Detection of left atrial appendage thrombus by cardiac computed tomography in patients with atrial fibrillation: a meta-analysis. Circ Cardiovasc Imaging. 2013; 6: 185–194. DOI: 10.1161/circimaging. 112.000153
25. Revishvili A.Sh., Strebkova ED, Artyukhina ЕА, et al. The effectiveness of thoracoscopic treatment of non-paroxysmal atrial fibrillation. Journal of Arrhythmology. 2023; 30(3): 23-31. DOI: 10.35336/VA-1160 [In Russ].
26. Ohtsuka T, Nonaka T, Hisagi M, et al. Thoracoscopic stapler-and-loop technique for left atrial appendage closure in nonvalvular atrial fibrillation: mid-term outcomes in 201 patients. Heart Rhythm. 2018; 15: 1314–1320. DOI: 10.1016/j.hrthm.2018.05.026
27. Bhuta S, Cao C, Pieper JA, et al. Cardiac magnetic resonance imaging for left atrial appendage closure planning. Pacing Clin Electrophysiol. 2023; 46(7): 745-751. DOI: 10.1111/ pace.14713
28. Karim N, Ho SY, Nicol E, et al. The left atrial appendage in humans: structure, physiology, and pathogenesis. Europace. 2020; 22(1): 5-18. DOI:10.1093/europace/euz212
29. Di Biase L. Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study. J Am Coll Cardiol. 2012. 60(6): 531-538. DOI: 10.1016/j.jacc.2012.04.032
30. Madden JL. Resection of the left auricular appendix; a prophylaxis for recurrent arterial emboli. J Am Med Assoc. 1949; 140: 769–772.
31. Wang Y, Di Biase L, Horton RP, et al. Left atrial appendage studied by computed tomography to help planning for appendage closure device placement. J Cardiovasc Electrophysiol. 2010; 21: 973–82. DOI: 10.1111/j.1540-8167.2010.01814.x
32. Di Biase L, Santangeli P, Anselmino M, et al. Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study. J Am Coll Cardiol. 2012; 60: 531–538. DOI: 10.1016/j.jacc.2012.04.032
33. Ho SY, Cabrera JA, Sanchez-Quintana D. Left atrial anatomy revisited. Circ Arrhythm Electrophysiol. 2012; 5: 220–8. DOI: 10.1161/circep.111.962720
34. Cabrera JA, Saremi F, Sanchez-Quintana D. Left atrial appendage: anatomy and imaging landmarks pertinent to percutaneous transcatheter occlusion. Heart. 2014; 100: 1636–50. DOI: 10.1136/heartjnl-2013-304464
35. Beigel R, Wunderlich NC, Ho SY, et al. The left atrial appendage: anatomy, function, and noninvasive evaluation. JACC Cardiovasc Imaging. 2014; 7: 1251–65. DOI: 10.1016/j.jcmg.2014.08.009
36. Vira T, Pechlivanoglou P, Connelly K, et al. Cardiac computed tomography and magnetic resonance imaging vs. transoesophageal echocardiography for diagnosing left atrial appendage thrombi. Europace. 2019; 21: e1–e10. DOI: 10.1093/europace/euy142
37. Lupercio F, Carlos Ruiz J, Briceno DF, et al. Left atrial appendage morphology assessment for risk stratification of embolic stroke in patients with atrial fibrillation: a meta-analysis. Heart Rhythm. 2016; 13: 1402–1409. DOI:10.1016/j.hrthm.2016.03.042
38. Lindner S, Behnes M, Wenke A, et al. Relation of left atrial appendage closure devices to topographic neighboring structures using standardized imaging by cardiac computed tomography angiography. Clin Cardiol. 2019; 42: 264–269. DOI:10.1002/clc.23136
39. Wongcharoen W, Tsao HM, Wu MH, et al. Morphologic characteristics of the left atrial appendage, roof, and septum: implications for the ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2006; 17: 951–956. DOI: 10.1111/j.1540-8167.2006.00549.x
40. Liu FZ, Lin WD, Liao HT, et al. Mid-term outcomes of concomitant left atrial appendage closure and catheter ablation for non-valvular atrial fibrillation: a multicenter registry. Heart Vessels. 2019; 34: 860–867. DOI: 10.1007/s00380-018-1312-4
41. Halkin A, Cohen C, Rosso R, et al. Left atrial appendage and pulmonary artery anatomic relationship by cardiac-gated computed tomography: implications for late pulmonary artery perforation by left atrial appendage closure devices. Heart Rhythm. 2016; 13: 2064–2069. DOI: 10.1016/j.hrthm.2016. 07.015
42. Wang YJ, Liu L, Zhang MC, et al. Imaging of pericardiophrenic bundles using multislice spiral computed tomography for phrenic nerve anatomy. J Cardiovasc Electrophysiol. 2016; 27: 961–971. DOI: 10.1111/jce.13003
43. Sanchez-Quintana D, Ho SY, Climent V, et al. Anatomic evaluation of the left phrenic nerve relevant to epicardial and endocardial catheter ablation: implications for phrenic nerve injury. Heart Rhythm. 2009; 6: 764–768. DOI: 10.1016/j.hrthm.2009.02.029
44. Beaver TM, Hedna VS, Khanna AY, et al. Thoracoscopic ablation with appendage ligation versus medical therapy for stroke prevention: a proof-of-concept randomized trial. Innovations (Phila). 2016; 11: 99–105. DOI: 10.1097/imi.0000000000000226
45. Ohtsuka T, Ninomiya M, Nonaka T, et al. Thoracoscopic stand-alone left atrial appendectomy for thromboembolism prevention in nonvalvular atrial fibrillation. J Am Coll Cardiol. 2013; 62: 103–107. DOI: 10.1016/j.jacc.2013.01.017
46. Caliskan E, Sahin A, Yilmaz M, et al. Epicardial left atrial appendage AtriClip occlusion reduces the incidence of stroke in patients with atrial fibrillation undergoing cardiac surgery. Europace. 2018; 20: e105–e114. DOI: 10.1093/europace/ eux211
47. Ailawadi G, Gerdisch MW, Harvey RL, et al. Exclusion of the left atrial appendage with a novel device: early results of a multicenter trial. J Thorac Cardiovasc Surg. 2011; 142: 1002–9. DOI: 10.1016/j.jtcvs.2011.07.052
48. Dawson AG, Asopa S, Dunning J. Should patients undergoing cardiac surgery with atrial fibrillation have left atrial appendage exclusion? Interact Cardiovasc Thorac Surg. 2010; 10: 306–11. DOI: 10.1510/icvts.2009.227991
Review
For citations:
Kadyirova M., Strebkova E.D., Yalova E.V., Revishvili A.Sh. Reoperative planning of thoracoscopic amputation of the left atrium appendage in atrial fibrillation. Minimally Invasive Cardiovascular Surgery. 2025;1(4):68-79. (In Russ.)
